Curriculum vitae

Personal Curriculum vitae 

Name： Yuan-Yu (Ben) Hsueh, M.D. Ph.D

Present Title and Affiliation：

Attending Plastic Surgeon
Clinical Associate Professor
Division of Plastic surgery, Department of Surgery,
National Cheng Kung University Hospital, Tainan, Taiwan

E-mail: yyhsueh@mail.ncku.edu.tw; benyyhsueh@gmail.com

Lab website:  

https://nckunmr.wordpress.com/

College Education：

1996.09 - 2003.06
Medical Doctor, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Post-Graduate Education：
2003.08~2005.07 

Resident at Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan

2005.08~2009.07

Resident at Section of Plastic Surgery, National Cheng Kung University Hospital, Tainan, Taiwan

2007.09~2010.6
Master, Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan

2011.09~2015.01 

PhD, Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, Taiwan

Academic Appointment：

2011.08~2015.07                            

Clinical Instructor, Department of Cell Biology & Anatomy, College of Medicine, National Cheng Kung University, Tainan, Taiwan

2014.08~2014.09 

Visiting Scholar, Department of Plastic Surgery, Tokyo University Hospital

2015.08~Present 

Clinical Assistant Professor, Department of Surgery, College of Medicine, National Cheng Kung University, Tainan, Taiwan

2017.07~2019.06 

Visiting Assistant Professor, Department of Bioengineering, University of California, Los Angeles, USA

Employment Record：

2003. 08~2005.07 

Resident at Department of Surgery, National Cheng Kung University Hospital, Tainan, Taiwan

2005.08~2009.07

Resident at Section of Plastic Surgery, National Cheng Kung University Hospital, Tainan, Taiwan

2009~Present

Attending Physician in National Cheng Kung University Hospital, Tainan

Board Certification：

2007.12 Board of Surgery #5708, Taiwan

2009.12 Board of Plastic Surgery #0505, Taiwan

2009.12 Board of Hand Surgery #684, Taiwan

Licensers：

2003/12 Board of Medicine #036339

Professional Affiliation：

2007~Present   Taiwan Surgical Association

2009~Present   Taiwan Society of Plastic Surgery

2009~Present   Taiwan Society for Surgery of Hand

2010~Present   Taiwan Society for Burn Injuries and Wound Healing

2013~Present   International member of American Society of Plastic Surgery

2014~Present   Taiwan Society for Reconstructive Microsurgery

Awards：

2016.04

Best Young Investigator Award of Basic Research, National Cheng Kung University Medical College

2015.06

Honorary member of the Phi Tau Phi Scholastic Honor Society of the Republic of China

2014.12

Award for Excellent of Medical Research Grant Poster Competition, National Cheng Kung University Hospital

2014.06

Outstanding Research Award of PhD student Oral Paper Competition, National Cheng Kung University Medical College

2014.02

1st Prize of Oral Paper Competition, Taiwan Association of Regenerative Medicine

2014.01

2nd Prize of Travel Grant Competition, TIGP-NCKU Neuroscience Retreat

2012.02

Award for Excellent of Oral Paper Competition, Taiwan Association of Regenerative Medicine

2010.12 

3rd Prize of Medical Research Grant Poster Competition, National Cheng Kung University Hospital

Personal Specialty

Clinical

1) Hand surgery: 

Hand trauma, Digit and limb replantation, Peripheral nerve surgery, Tendon surgery, Electrical stimulation

2) Body contouring surgery:

Liposuction, Autologous fat transfer

3) Scar surgery:

Keloid and hypertrophic scar surgery, Scar revision and smoothening

4) Stem cell therapy:

Autologous adipose stem cell regenerative therapy

Research

1) Stem cell research:

Adipose stem cell, Neural stem cell, Endothelial stem cell

2) Regenerative medicine:

Peripheral nerve regeneration, Electrical stimulation, Neuromodulation, Wound healing and tissue regeneration, Angiogenesis

3) Scar research:

Pathophysiology and therapeutic target of keloid and hypertrophic scar

Published Paper

• Chia-Bao Chu, Chao-Chun Yang, Yuan-Yu Hsueh, Po-Chuan Chen, Yi-Kai Hong, Yu-Yun Kuo, Shaw-Jenq Tsai. Aberrant expression of IL-17A in mast cells contributes to the pathogenesis of hidradenitis suppurativa. Br J Dermatol. 2023 Aug 4;ljad273. doi: 10.1093/bjd/ljad273
• Szu-Han Chen , Chia-Ching Wu, Wan-Ling Tseng, Fu-I Lu, Ya-Hsin Liu, Shau-Ping Lin, Sheng-Che Lin , Yuan-Yu Hsueh*. Adipose-derived stem cells modulate neuroinflammation and improve functional recovery in chronic constriction injury of the rat sciatic nerve. Front Neurosci. 2023 Jun 29;17:1172740
• Ming-Wei Hsu, Szu-Han Chen, Wan-Ling Tseng, Kuo-Shu Hung, Tzu-Chun Chung, Sheng-Che Lin, Jahyun Koo, Yuan-Yu Hsueh*. Physical processing for decellularized nerve xenograft in peripheral nerve regeneration. Front. Bioeng. Biotechnol. 2023 May 30; 11:1217067.
• Meng-Wei Lin, Yu-Tzu Chang, Yuan-Yu Hsueh*, Hyperosmolar Hyperglycemic Crisis After Burn Injury in a Patient With Advanced Amyotrophic Lateral Sclerosis: A Case Report. Annals of Plastic Surgery 2022 Oct 1;89(4):373-375
• Woo-Youl Maeng, Wan-Ling Tseng, Song Li, Jahyun Koo, Yuan-Yu Hsueh*, Electroceuticals for peripheral nerve regeneration. Biofabrication 2022 Aug 17;14(4):042002-042021
• Anjali Yadav, Thamil Selvee Ramasamy, Sheng-Che Lin, Szu-Han Chen, Jean Lu, Ya-Hsin Liu, Fu-I Lu, Yuan-Yu Hsueh, Shau-Ping Lin, Chia-Ching Wu. Autologous Platelet-Rich Growth Factor Reduces M1 Macrophages and Modulates Inflammatory Microenvironments to Promote Sciatic Nerve Regeneration Biomedicines. 2022 Aug 17;10(8):1991.
• Wei-Yu Tsai, Yuan-Yu Hsueh, Pei-Yu Chen, Kuo-Shu Hung, Chih-Chung Huang. High-Frequency Ultrasound Elastography for Assessing Elastic Properties of Skin and Scars. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 Jun;69(6):1871-1880
• LeeAnn K Li, Wen-Chin Huang, Yuan-Yu Hsueh, Ken Yamauchi, Natalie Olivares, Raul Davila, Jun Fang, Xili Ding, Weikang Zhao, Jennifer Soto, Mahdi Hasani, Bennett Novitch, Song Li. Intramuscular delivery of neural crest stem cell spheroids enhances neuromuscular regeneration after denervation injury. Stem Cell Research & Therapy 2022 May 16;13(1):205-218.
• Anjali Yadav, Tzu‐Chieh Huang, Szu‐Han Chen, Thamil Selvee Ramasamy, Yuan‐Yu Hsueh, Shau‐Ping Lin, Fu‐I Lu, Ya‐Hsin Liu, Chia‐Ching Wu. Sodium phenylbutyrate inhibits Schwann cell inflammation via HDAC and NFκB to promote axonal regeneration and remyelination. Journal of Neuroinflammation. 2021 Oct 16;18(1):238
• An Huang, Yi-Shiuan Lin, Ling-Zhen Kao, Yu-Wei Chiou, Gang-Hui Lee, Hsi-Hui Lin, Chih-Hsing Wu, Chin-Sung Chang, Kuo-Ting Lee, Yuan-Yu Hsueh, Pei-Jane Tsai, Ming-Jer Tang, Yau-Sheng Tsai. Inflammation-induced macrophage lysyl oxidase in adipose stiffening and dysfunction in obesity. Clinical and Translational Medicine. 2021 Sep;11(9):e543
• Jun Fang, Junren Sia, Jennifer Soto, Pingping Wang, LeeAnn K Li, Yuan-Yu Hsueh. Raymond Sun, Kym Francis Faull, James G Tidball, Song Li, Skeletal muscle regeneration via the chemical induction and expansion of myogenic stem cells in situ or in vitro.Nature Biomedical Engineering 2021 Aug;5(8):864-879
• Szu-Han Chen, Chia-Ching Wu, Sheng-Che Lin, Wan-Ling Tseng, Tzu-Chieh Huang, Anjali Yadav, Fu-I Lu, Ya-Hsin Liu, Shau-Ping Lin, Yuan-Yu Hsueh*. Investigation of neuropathology after nerve release in chronic constriction injury of rat sciatic nerve. International Journal of Molecular Sciences 2021 Apr 29; 22(9):4746-4763
• Yeu-Her Lai, Li-Wen Chen, Yuan-Yu Hsueh*. Delayed neurological sequelae in an infant after carbon monoxide intoxication. Journal of Burn Care and Research 2021 Sep 30;42(5):1035-1037
• Yeon Sik Choi#, Yuan-Yu Hsueh#, Jahyun Koo#, Quansan Yang#, Buwei Hu, Zhaoqian Xie, Raudel Avila, Geumbee Lee, Ning Zheng, Claire Liu, Yameng Xu, Young Joong Lee, Weikan Zhao, Jun Fang, Yujun Deng, Seung Min Lee, Iwona Stepien, Ying Yan, Joseph Song, Chad Haney, Yong Suk Oh, Wentai Liu, Hong-Joon Yoon, Anthony Banks, Matthew MacEwan, Guillermo Ameer, Wilson Ray, Yonggang Huang ,Colin Franz, Tao Xie, Song Li, Abraham Vazquez-Guardado, John A. Rogers. Stretchable, dynamic covalent polymers for soft, long-lived bioresorbable electronic stimulators designed to facilitate neuromuscular regeneration. Nature Communications 2020; 11(1):5990-6003
• Szu-Han Chen, Tzu-Chieh Huang, Jheng-Yang Wang, Chia-Ching Wu, Yuan-Yu Hsueh*. Controllable Forces for Reproducible Chronic Constriction Injury Mimicking Compressive Neuropathy in Rat Sciatic Nerve. J Neurosci Methods. 2020 Apr 1;335:108615
• Jun Fang, Yuan-Yu Hsueh, Jennifer Soto, Wujin Sun, Jinqiang Wang, Zhen Gu, Ali Khademhosseini, Song Li. Engineering Biomaterials With Micro/Nanotechnologies for Cell Reprogramming. ACS Nano. 2020 Feb 25;14(2):1296-1318
• Chia-Wei Huang, Shih-Yu Lu, Tzu-Chieh Huang, Bu-Miim Huang, H. Sunny Sun, Shang-Hsun Yang, Jih-Ing Chuang, Yuan-Yu Hsueh, Yi-Ting Wu, Chia-Ching Wu. FGF9 induces functional differentiation to Schwann cells from human adipose derived stem cells. Theranostics. 2020; 10(6): 2817-2831
• Ching-Wen Huang, Yuan-Yu Hsueh, Wen-Chin Huang, Shyam Patel, Song Li. Multipotent vascular stem cells contribute to neurovascular regeneration of peripheral nerve. Stem Cell Research & Therapy 2019; 10(1):234-42.
• Tzu-Yen Chang , Yuan-Yu Hsueh, Yen Yi-Ting, Jing-Wei Lee. Factors affecting functional outcomes following mangled lower limb injury. Asian J Surg. 2019 May;42(5):644-646
• Chein-Hong Lin, Po-Yuan Chiu, Yuan-Yu Hsueh, Shyh-Jou Shieh, Chia-Ching Wu, Tak-Wah Wong, Cheng-Ming Chuong, Michael W. Hughes. Regeneration of rete ridges in Lanyu pig (Sus scrofa): Insights for human skin wound healing. Exp Dermatol. 2019 Apr;28(4):472-479
• Wei-Ting Hsueh, Kuo-Shu Hung, Yu-Chen Chen, Yen-Tsung Huang, Chao-Kai Hsu, Rei Ogawa, and Yuan-Yu Hsueh*. Adjuvant Radiotherapy After Keloid Excision: Preliminary Experience in Taiwan. Annals of Plastic Surgery 2019; 82(1S Suppl 1):S39-S44. 
• Tzu-Yen Chang, Yao-Chou Lee, You-Cheng Lin, Stanley Thian-Sze Wong, Yuan-Yu Hsueh, Yao-Lung Kuo, Shyh-Jou Shieh, Jing-Wei Lee. Implantable Doppler Probes for Postoperatively Monitoring Free Flaps: Efficacy. A Systematic Review and Meta-analysis. Plast Reconstr Surg Glob Open. 2016 Nov;4(11):e1099
•  Yuan-Yu Hsueh, Duo-Hsiang Wang, Tzu-Chieh Huang, Ya-Ju Chang, Wei-Chi Shao, Tai-Lan Tuan, Michael W. Hughes, Chia-Ching Wu, Novel skin chamber for rat ischemic flap studies in regenerative wound repair. Stem Cell Research & Therapy 2016; 7(1):72-80.
• Chin-Fu Huang, Ya-Ju Chang, Yuan-Yu Hsueh, Chia-Wei Huang, Duo-Hsiang Wang, Tzu-Chieh Huang, Yi-Ting Wu, Fong-Chin Su, Michael Hughes, Cheng-Ming Chuong, Chia-Ching Wu. Assembling Composite Dermal Papilla Spheres with Adipose-derived Stem Cells to Enhance Hair Follicle Induction. Scientific Reports 2016 May; 23(6):26436-26447.
• Ya-Ju Chang, Hui-Chun Huang, Yuan-Yu Hsueh, Shao-Wei Wang, Fong-Chin Su, Chih-Han Chang, Ming-Jer Tang, Yi-Shuan Li, Shyh-Hau Wang, Kirk K. Shung, Shu Chien, Chia-Ching Wu. Role of Excessive Autophagy Induced by Mechanical Overload in Vein Graft Neointima Formation: Prediction and Prevention. Scientific Reports 2016 Feb; 26(6):22147-22157
•  Yuan-Yu Hsueh, Ya-Ju Chang, Chia-Wei Huang, Fitri Handayani, Yi-Lun Chiang, Shih-Chen Fan, Chien-Jung Ho, Yu-Min Kuo, Shang-Hsun Yang, Yuh-Ling Chen, Sheng-Che Lin, Chao-Ching Huang, Chia-Ching Wu. Synergy of endothelial and neural progenitor cells from adipose-derived stem cells to preserve neurovascular structures in rat hypoxic-ischemic brain injury. Scientific Reports 2015 Oct; 8(5):14985-14996.
• Chia-Wei Huang, Chao-Ching Huang, Yuh-Ling Chen, Shih-Chen Fan, Yuan-Yu Hsueh, Chien-Jung Ho, Chia-Ching Wu. Shear Stress Induces Differentiation of Endothelial Lineage Cells to Protect Neonatal Brain from Hypoxic-Ischemic Injury through NRP1 and VEGFR2 Signaling. Biomed Res Int. 2015;2015:862485
• Tzu-yen Chang, Shin-Chen Pan, Yi-Hsun Huang, Yuan-Yu Hsueh*. Blindness after calcium hydroxylapatite injection at nose. Journal of Plastic, Reconstructive & Aesthetic Surgery 2014 Dec; 67(12):1755-1757.
• Yuan-Yu Hsueh, Wei-Chen Chen, Haw-Yen Chiu. Idiopathic subluxation of extensor pollicis longus and brevis tendon: a cause of congenital clasped thumb. Journal of Hand Surgery: European Volume 2014 Mar; 39(3):325-326. 
• Yuan-Yu Hsueh, Ya-Ju Chang, Tzu-Chieh Huang, Shih-Chen Fan, Duo-Hsiang Wang, Jia-Jin Jason Chen, Chia-Ching Wu, Sheng-Che Lin. Functional recoveries of sciatic nerve regeneration by combining chitosan-coated conduit and neurosphere cells induced from adipose-derived stem cells. Biomaterials 2014 Feb; 35(7):2234-2244
• Wei-Chen Chen, Yuan-Yu Hsueh*. Primary dermal melanoma in a 19-year-old asian man. Dermatologic Surgery 2013 Apr; 39(4):662-665.
• Yuan-Yu Hsueh, Yi-Lun Chiang, Chia-Ching Wu, Sheng-Che Lin. Spheroid formation and neural induction in human adipose-dervived stem cells on a chitosan-coated surface. Cells Tissues Organs 2012; 196(2):117-128.
• Yuan-Yu Hsueh, Chung-Lin Chen, Shin-Chen Pan. Response to letter to the editor: Comments on ”Analysis of factors influencing limb amputation in high-voltage electrically injured patients”. Burns 2011; 37(8):1459-1460.
• Yuan-Yu Hsueh, Shyh-Jou Shieh, Haw-Yen Chiu. Revascularization and dynamic distraction for a complex finger injury. Journal of Hand Surgery: European Volume 2010; 35(9):762-764.
• Jing-Wei Lee, Yuan-Yu Hsueh, Jung-Shun Lee. Composite skull and dura defect reconstruction using combined latissimus dorsi musculocutaneous and serratus anterior muscle-rib free flap coupled with vascularized galea transfer: A case report. Microsurgery 2010; 30(8):632-635.
• Yuan-Yu Hsueh, Shyh Jou Shieh. Two-stage retroauricular flap to reconstruct a helical rim defect. Dermatologic Surgery 2009; 35(11):1827-1830.